Keywords: Contrast Agents, Liver, Magnetic resonance imaging; Glypican; Gadobenate‑dimeglumine; Nomogram
Motivation: The expression level of Glypican-3 (GPC-3) is closely associated with the malignancy and prognosis of HCC.
Goal(s): To investigate the predictive value of a nomogram based on clinical factors and gadobenate dimeglumine-enhanced MRI for predicting the expression of GPC-3 in HCC.
Approach: The preoperative clinical data,gadobenate dimeglumine-enhanced MRI features and pathological GPC-3 expression of 185 HCC patients were retrospectively collected.Nomogram model for predicting GPC-3 expression in patients was established.
Results: Significant differences in AFP,intratumoral hemorrhage,and TLR-HBP were found between GPC-3 positive and negative HCC groups.The nomogram model integrating clinical and MRI parameters demonstrated superior predictive performance for GPC-3 expression compared to individual indicators.
Impact: Early noninvasive prediction of GPC-3 expression provides guidance for prognosis assessment and tumor treatment. A nomogram based on clinical and gadobenate dimeglumine-enhanced MRI can effectively predict GPC-3 expression in HCC,helping clinicians evaluate prognosis and select appropriate treatments for HCC patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords