Keywords: Microstructure, Microstructure, Gray Matter, Biomarkers, Diffusion Modelling, Magnetization Transfer, Neuro, Multi-Contrast, Multimodal, Contrast Mechanisms, Brain
Motivation: The NEXI model aims to characterize gray matter microstructure. Validation against established techniques is crucial for assessing its sensitivity, specificity, and clinical potential.
Goal(s): Evaluate NEXI against ihMT and MPF, highly sensitive biomarkers of tissue myelination.
Approach: Compare NEXI maps against MPF and ihMT in the human cortex.
Results: ihMT ratio correlated exclusively with exchange time (tex, cell-membrane permeability proxy), while MPF correlated exclusively with cell process density (f). High ihMTR/MPF patterns matched high tex/f patterns in myelin-rich regions. Discrepancies indicate unique contributions from different cell populations and can offer insights into distinct microstructural features, enhancing our understanding of brain tissue composition in-vivo.
Impact: We performed a cross-validation of the sensitivity of NEXI-derived membrane permeability with myelin content, and neurite density with macromolecular proton fraction in the human brain, thus paving the way for the translation of NEXI to studies on patient populations.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords