Keywords: Microstructure, Multimodal
Motivation: To systematically investigate the alterations of superficial white matter (SWM) in ALS.
Goal(s): We aimed to assess SWM microstructural changes and their associations with neural dysfunction and disease severity in ALS.
Approach: SWM microstructural impairments were evaluated through neurite orientation dispersion and density imaging. Functional disturbances within cortical regions corresponding to compromised SWM were measured by regional homogeneity (ReHo) . Disease severity was assessed using the revised ALS Functional Rating Scale (ALSFRS-R).
Results: ALS patients exhibited alternations in NDI value and ReHo value in specific SWM regions. Furthermore, cortical ReHo alterations mediated the relationship between SWM NDI value and the ALSFRS-R score.
Impact: Focusing on SWM evaluation offers a new perspective on the interaction between structural and functional disruptions in ALS, highlighting a crucial neurobiological substrate related to disease progression.
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