Keywords: Microstructure, Diffusion Modeling, Temporal Lobe Epilepsy; Cognitive Impairment; Hippocampus; NODDI.
Motivation: Temporal lobe epilepsy (TLE) significantly impacts patients’ quality of life, with cognitive impairment (CI) being a common comorbidity. Understanding hippocampal microstructure changes is crucial for diagnosing TLE and its associated CI.
Goal(s): To investigate hippocampal microstructure differences between TLE patients with CI (TLE-CI) and those with normal cognition (TLE-CN) using NODDI technology.
Approach: 66 TLE patients and 40 healthy controls underwent NODDI imaging. NODDI metrics were analyzed to assess microstructural differences and their correlation with clinical characteristics.
Results: TLE-CI patients showed significant hippocampal microstructural abnormalities, with elevated fiso values and reduced NDI values, correlating with earlier epilepsy onset and longer disease duration.
Impact: This study’s findings on hippocampal microstructural abnormalities in TLE-CI patients can guide early diagnosis and surgical treatments, potentially improving cognitive outcomes. It opens avenues for further research on bilateral impacts of unilateral TLE and long-term disease progression.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords