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Abstract #3910

Investigating Hippocampal Microstructural Differences in Temporal Lobe Epilepsy Patients with Cognitive Impairment Using NODDI

Wenrui Yang 1, Yuhui Xiong1,2, Hao Ye3, and Bing Chen1
1Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan, China, 2GE HealthCare MR Research, Beijing, China, 3School of the first Clinical Medicine, Ningxia Medical University, Yinchuan, China

Synopsis

Keywords: Microstructure, Diffusion Modeling, Temporal Lobe Epilepsy; Cognitive Impairment; Hippocampus; NODDI.

Motivation: Temporal lobe epilepsy (TLE) significantly impacts patients’ quality of life, with cognitive impairment (CI) being a common comorbidity. Understanding hippocampal microstructure changes is crucial for diagnosing TLE and its associated CI.

Goal(s): To investigate hippocampal microstructure differences between TLE patients with CI (TLE-CI) and those with normal cognition (TLE-CN) using NODDI technology.

Approach: 66 TLE patients and 40 healthy controls underwent NODDI imaging. NODDI metrics were analyzed to assess microstructural differences and their correlation with clinical characteristics.

Results: TLE-CI patients showed significant hippocampal microstructural abnormalities, with elevated fiso values and reduced NDI values, correlating with earlier epilepsy onset and longer disease duration.

Impact: This study’s findings on hippocampal microstructural abnormalities in TLE-CI patients can guide early diagnosis and surgical treatments, potentially improving cognitive outcomes. It opens avenues for further research on bilateral impacts of unilateral TLE and long-term disease progression.

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