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Abstract #3911

Iron Deficiency Anemia is associated with extensive white matter damage: A diffusion kurtosis analysis

Samantha Mejia1, Clio González-Zacarías1,2, Emma Carpenter1,3, Hannah Salcudean1, Botian Xu1,4, Silvie Suriany1, Sneha Verma1, Anand A. Joshi2, Peter Chiarelli5,6, Richard M. Leahy2, and John C. Wood1,7
1Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, 2Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, 3Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States, 4Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 5Pediatric Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, United States, 6Clinical Neurological Surgery, Keck School of Medicine of USC, Los Angeles, CA, United States, 7Pediatrics and Radiology, Keck School of Medicine of USC, Los Angeles, CA, United States

Synopsis

Keywords: DWI/DTI/DKI, Diffusion Acquisition, Kurtosis, Tensor, NODDI, Iron, Anemia, Iron Deficiency Anemia

Motivation: Women with iron deficiency anemia (IDA) experience significant neurocognitive and motor deficits, which could result from white matter (WM) damage.

Goal(s): To examine WM changes on diffusion MRI caused by IDA.

Approach: We quantified the diffusion kurtosis tensor in 35 female IDA patients and 19 healthy controls. Then, we performed a voxel-wise analysis controlling for blood markers of anemia.

Results: Increased radial and mean kurtosis was observed in the entire WM, well beyond watershed areas impacted by ischemic processes, suggesting diffusely impaired myelin maintenance. Our findings suggest that IDA impacts WM health through factors beyond hypoxia alone.

Impact: In iron deficiency anemia, Kurtosis imaging showed significant differences in WM with respect to controls; not linked to the anemia severity but consistent with demyelination processes. Our findings highlight the importance of timely diagnosis and treatment to prevent WM degeneration.

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Abstract

Keywords