Keywords: Simulation/Validation, DWI/DTI/DKI, Collagen, Fiber, Tendon, Dispersion, Anisotropy
Motivation: Collagen fiber orientation and dispersion are important determinants of the mechanical behavior of soft tissues such as tendon. DTI can provide the bulk collagen fiber orientation of a voxel, but the quantitative relationship between the shape of the diffusion tensor and the intra-voxel fiber dispersion remains unclear.
Goal(s): Determine the relationship between the diffusion tensor and intra-voxel collagen fiber dispersion of tendon via simulation.
Approach: We simulated a diffusion MRI sequence within collagen fiber networks of known dispersion to determine the impact of fiber dispersion on diffusion MRI measurements.
Results: Increased fiber dispersion is non-linearly associated with decreased axial diffusivity and fractional anisotropy.
Impact: The relationships developed in this work will be used in subject- and tissue-specific DTI-based mechanical models of fibrous tissue. Such models can be used to predict mechanical behavior and the potential origins of failure.
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