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Abstract #3918

Impact of fiber dispersion in collagenous soft tissue on diffusion MRI metrics

Michael D. K. Focht1, Mariana E. Kersh1, Amir O. Moghaddam2, Amy J. Wagoner Johnson1, and Noel M. Naughton3
1Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, United States, 2University of Nebraska-Lincoln, Lincoln, NE, United States, 3Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States

Synopsis

Keywords: Simulation/Validation, DWI/DTI/DKI, Collagen, Fiber, Tendon, Dispersion, Anisotropy

Motivation: Collagen fiber orientation and dispersion are important determinants of the mechanical behavior of soft tissues such as tendon. DTI can provide the bulk collagen fiber orientation of a voxel, but the quantitative relationship between the shape of the diffusion tensor and the intra-voxel fiber dispersion remains unclear.

Goal(s): Determine the relationship between the diffusion tensor and intra-voxel collagen fiber dispersion of tendon via simulation.

Approach: We simulated a diffusion MRI sequence within collagen fiber networks of known dispersion to determine the impact of fiber dispersion on diffusion MRI measurements.

Results: Increased fiber dispersion is non-linearly associated with decreased axial diffusivity and fractional anisotropy.

Impact: The relationships developed in this work will be used in subject- and tissue-specific DTI-based mechanical models of fibrous tissue. Such models can be used to predict mechanical behavior and the potential origins of failure.

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