Keywords: Infectious Disease, COVID-19, Longitudinal, Fatigue, Spectroscopy
Motivation: Long-term post-COVID syndrome involves lasting symptoms including chronic-fatigue-syndrome or myalgic-encephalomyelitis(CFS/ME). We aim to investigate longitudinal changes in mitochondrial dysregulation and neurochemical abnormalities, which may be linked to the recovery of the post-COVID syndrome.
Goal(s): We seek to evaluate longitudinal changes in post-COVID CFS/ME patients in relation to neurochemical markers of neuroinflammation, redox imbalance, and neuronal dysfunction.
Approach: Ten-patients with post-COVID CFS/ME were scanned using proton MRS at two-time points targeting at posterior cingulate gyrus(PCG).
Results: Overall neuronal activity recovered in patients with post-COVID CFS/ME as well as chronic fatigue scores, but the recovery did not reach the levels observed in other metabolic information.
Impact: A longitudinal assessment of neurochemical metabolites in PCG reveals that while neuronal activity may recover, clinical symptoms of post-COVID fatigue can persist, potentially alongside markers of mitochondrial dysfunction that show no improvement over time.
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