Keywords: Infectious Disease, Infectious disease
Motivation: COVID-19 negatively impacts brain health, with clinical MRI showing a wide range of neurologic manifestations but no consistent pattern.
Goal(s): Determine whether differences exist in white matter hyperintensity (WMH) burden, hippocampal volume, and cognitive function between COVID-19 patients with and without hospitalization.
Approach: 190 participants were scanned at 7T across three USA and one UK sites. MP2RAGE, FLAIR, and TSE sequences were analyzed.
Results: We observed similar WMH, smaller hippocampal volumes, and poorer cognitive performance in age-matched hospitalized patients.
Impact: This study contributes to understanding the neurological impact of COVID-19, revealing that hospitalized patients experience hippocampal volume reduction and cognitive decline. It emphasizes the utility of advanced 7T MRI in detecting subtle brain changes, guiding future research and clinical care.
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