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Abstract #3934

Examining White Matter Hyperintensities, Hippocampal Subfields, and Cognitive Function in Recovered COVID-19 Patients

Jr-Jiun Liou1, Tales Santini1, Jinghang Li1, Monica Gireud-Goss2, Vibhuti Patel2, Oluwatobi Adeyemi3, Gabriel de Erausquin2, Valentina Garbarino2, Mohamad Habes2, Jayandra Himali2, Christof Karmonik4, Beth Snitz1, Joseph Mettenburg1, Minjie Wu1, Howard Aizenstein1, Anna Marsland1, Peter Gianaros1, Farhaan Vahidy4, Timothy Girard1, Heidi Jacobs5, Akram Hosseini3, Sudha Seshadri2, and Tamer Ibrahim1
1University of Pittsburgh, Pittsburgh, PA, United States, 2University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 3University of Nottingham, Nottingham, United Kingdom, 4Houston Methodist Research Institute, Houston, TX, United States, 5Harvard University, Boston, MA, United States

Synopsis

Keywords: Infectious Disease, Infectious disease

Motivation: COVID-19 negatively impacts brain health, with clinical MRI showing a wide range of neurologic manifestations but no consistent pattern.

Goal(s): Determine whether differences exist in white matter hyperintensity (WMH) burden, hippocampal volume, and cognitive function between COVID-19 patients with and without hospitalization.

Approach: 190 participants were scanned at 7T across three USA and one UK sites. MP2RAGE, FLAIR, and TSE sequences were analyzed.

Results: We observed similar WMH, smaller hippocampal volumes, and poorer cognitive performance in age-matched hospitalized patients.

Impact: This study contributes to understanding the neurological impact of COVID-19, revealing that hospitalized patients experience hippocampal volume reduction and cognitive decline. It emphasizes the utility of advanced 7T MRI in detecting subtle brain changes, guiding future research and clinical care.

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Keywords