Meeting Banner
Abstract #3935

DTI and DKI with Free Water Elimination Reveal Compounded Microstructural brain abnormalities in People with HIV with Chronic Marijuana Use

Teddy Salan1, Denise Vidot1, Allan Rodriguez1, Suresh Pallikkuth1, Eva Widerstrom-Noga1, Linda Robayo1, Sulaiman Sheriff1, Robert Cook2, and Varan Govind1
1University of Miami, Miami, FL, United States, 2University of Florida, Gainesville, FL, United States

Synopsis

Keywords: Infectious Disease, Infectious disease

Motivation: Microstructural brain abnormalities are well documented in people with HIV (PWH). However, the effects of long-term marijuana use on white matter integrity are less established.

Goal(s): The goal of this study is to examine if HIV infection and chronic marijuana use have differential or additive effect on white matter abnormalities.

Approach: We use DTI/DKI with Free water elimination to evaluate diffusivity metrics at regions of interest in the whole-brain.

Results: Our findings show that white matter injury is more severe in people with HIV with chronic marijuana use compared to HIV or marijuana alone.

Impact: This study demonstrates the additive effect of HIV infection and chronic marijuana use on white matter microstructural integrity using multi-shell DTI and DKI with Free-water elimination.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords