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Abstract #3936

Assessing Iron and Myelin Alterations in Patients with COVID-19 Using χ-separation

Md Nasir Uddin1, Abrar Faiyaz1, and Giovanni Schifitto1
1Department of Neurology, University of Rochester, Rochester, NY, United States

Synopsis

Keywords: Neuroinflammation, Brain, Iron, Myelin, Susceptibility, MRI, Neuroimaging, COVID-19

Motivation: COVID-19 affects the CNS, leading to persistent neurological complications. Alterations in brain iron levels and myelin integrity are suspected contributors. Accurate measurement of these minerals is crucial for understanding COVID-19-related neurological issues.

Goal(s): This study investigates abnormal iron accumulation and demyelination in COVID cases using 𝜒-separation.

Approach: We analyzed 132 subjects across three groups-no COVID (n=41), mild COVID (n=33) and long COVID (n=58) scanned at 3T Siemens Prisma MRI.

Results: Significant differences in paramagnetic and diamagnetic susceptibilities and R2* values were observed in several white matter regions, while QSM showed no significant differences across groups.

Impact: These findings may help identify biomarkers for COVID-19 related brain involvement and guide therapeutic approaches.

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