Keywords: Neuroinflammation, Brain, Iron, Myelin, Susceptibility, MRI, Neuroimaging, COVID-19
Motivation: COVID-19 affects the CNS, leading to persistent neurological complications. Alterations in brain iron levels and myelin integrity are suspected contributors. Accurate measurement of these minerals is crucial for understanding COVID-19-related neurological issues.
Goal(s): This study investigates abnormal iron accumulation and demyelination in COVID cases using 𝜒-separation.
Approach: We analyzed 132 subjects across three groups-no COVID (n=41), mild COVID (n=33) and long COVID (n=58) scanned at 3T Siemens Prisma MRI.
Results: Significant differences in paramagnetic and diamagnetic susceptibilities and R2* values were observed in several white matter regions, while QSM showed no significant differences across groups.
Impact: These findings may help identify biomarkers for COVID-19 related brain involvement and guide therapeutic approaches.
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