Keywords: Neuroinflammation, Quantitative Susceptibility mapping, oxygenation, OEF ME/CFS, long COVID
Motivation: Patients with long COVID share many symptoms, such as fatigue and cognitive issues, with individuals with ME/CFS. Studying the similarities and differences between these related conditions can deepen our understanding of their disease mechanisms.
Goal(s): This study aims to measure regional cerebral oxygen extraction fraction (OEF) in ME/CFS patients with and without long COVID and compare them to controls.
Approach: Using QSM venography, we established a calibration curve and quantified oxygenation in major brain-draining veins.
Results: We found significantly lower oxygenation in the straight sinus in PASC patients compared to controls, suggesting elevated OEF in the deep brain regions.
Impact: This research reveals altered cerebral oxygenation in PASC ME/CFS patients compared to healthy controls, highlighting differences in oxygen extraction. These findings support further studies on brain oxygen metabolism in post-viral fatigue, with potential diagnostic and therapeutic implications.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords