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Abstract #3937

QSM venography measurement of regional cerebral blood oxygenation in PASC and ME/CFS

Zhanhao Liu1,2, Wenbo Li3, Benjamin Natelson4, Xu Li3,5, and Xiang Xu1
1BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Tandon School of Engineering, New York University, New York, NY, United States, 3F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Neuroinflammation, Quantitative Susceptibility mapping, oxygenation, OEF ME/CFS, long COVID

Motivation: Patients with long COVID share many symptoms, such as fatigue and cognitive issues, with individuals with ME/CFS. Studying the similarities and differences between these related conditions can deepen our understanding of their disease mechanisms.

Goal(s): This study aims to measure regional cerebral oxygen extraction fraction (OEF) in ME/CFS patients with and without long COVID and compare them to controls.

Approach: Using QSM venography, we established a calibration curve and quantified oxygenation in major brain-draining veins.

Results: We found significantly lower oxygenation in the straight sinus in PASC patients compared to controls, suggesting elevated OEF in the deep brain regions.

Impact: This research reveals altered cerebral oxygenation in PASC ME/CFS patients compared to healthy controls, highlighting differences in oxygen extraction. These findings support further studies on brain oxygen metabolism in post-viral fatigue, with potential diagnostic and therapeutic implications.

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