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Abstract #3938

Altered rostral anterior cingulate cortex GABA levels and excitation/inhibition imbalance in post-COVID-19 patients

Yanfei Bi1, Xiuzheng Yue2, Fei Gao1, Fuxin Ren1, and Xinwu Ma1
1Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 2Philips Healthcare, Beijing, China

Synopsis

Keywords: fMRI Acquisition, COVID-19, SARS-CoV-2, GABA, Glx (Glu + Gln), rACC, dACC, E/I imbalance

Motivation: This study aimed to explore the causes of neuropsychiatric disorders observed in patients long after COVID-19 infection.

Goal(s): Abnormal metabolite levels and excitation/inhibition imbalance in the rACC may contribute to the development of neuropsychiatric disorders.

Approach: The macromolecules(MM)-suppressed MEGA-PRESS sequence were employed to assess the levels of GABA and GLX.

Results: Higher GABA levels in the rostral ACC predicted more severe depressive state in the post-COVID-19 patients.Rostral ACC excitation-inhibition (EI) balance decreased in the post-COVID-19 patients

Impact: This study suggests that modulating metabolite levels could serve as a potential therapeutic approach for post-COVID-19 sequelae.

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Keywords