Abstract #3951

Cerebral blood velocity of small intracortical blood vessels in macaque monkey measured by quantitative phase-contrast MRI at 7T

Jianbao Wang^1,2,3, Yuqi Feng^2,4, An Ping², Feiyan Tian^2,3, Meixuan Chen^2,3, Yipeng Liu², Libo Lin⁴, Yi-Chang Hsu⁵, Anna Wang Roe^2,3,4, and Jonathan R. Polimeni^6,7,8

¹Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, China, ²Department of Neurosurgery of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, China, ³MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Hangzhou, China, ⁴Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, Hangzhou, China, ⁵MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China, ⁶Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁷Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁸Harvard/MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Blood Vessels, Velocity & Flow, Non-human primate; Intracortical vessels

Motivation: Fine-scale functions of the cerebral cortex are shaped by vascular hemodynamics; however, there is still a lack of knowledge about the velocity of small intracortical vessels in primates.

Goal(s): To quantify the cerebral blood velocity of small intracortical vessels in non-human primates using a conventional human 7 T scanner.

Approach: Using non-human primate model, phase-contrast MRA images were acquired using a 7T large-bore MRI scanner with 64-μm in-plane resolution.

Results: We show the accessibility to measure blood velocity of small intracortical vessels using a 7T large-bore MRI scanner. The mean blood velocity and radius of intracortical vessels are 7.3 mm/s and 43 μm.

Impact: Using a standard human 7T MRI scanner, we measured the velocity of micron-scale intracortical vessels non-invasively in primates. This study paves the way to understand intracortical vessel function in relation to functional organization and clinical application using non-human primate model.

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