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Abstract #3953

White mater hyperintensities and microplastics

Elaine L Bearer1, Natalie Adolphi1, Marcus A Garcia1, and Matthew J Campen1
1University of New Mexico Health Sciences Center, Albuquerque, NM, United States

Synopsis

Keywords: Alzheimer's Disease, biology, models, methods, microplastics, correlation MR-optical imaging

Motivation: White matter hyperintensities are abnormalities that appear in MRI scans of living patients but are not apparent in MRI post-mortem.

Goal(s): Our goal is to understand the cellular/biological basis of white matter hyperintensities.

Approach: We aligned post-mortem MR scans with those collected antemortem preformed histopathology and pyrGC/MS on regions with WMH.

Results: PyrGC/MS detected large amounts of plastics and detected their cellular location with a novel optical imaging approach in location with small vessel disease and Abeta plaques.

Impact: Microplastics in the brain of people with cognitive impairment may be due to pre-existing vascular injury or contribute to it. Many questions remain: Where do they come from, does they impair functional? Can they be diagnosed by MRI ante-mortem?

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Keywords