Keywords: White Matter, Neurodegeneration, White matter stroke
Motivation: Lesions caused by white matter strokes are a significant contributor to neurodegeneration.
Goal(s): To study the mechanisms leading to pathology, and to develop therapies to treat or prevent white matter stroke, animal models and suitable biomarkers are needed.
Approach: Here, we used T2 weighted MRI and DTI to measure lesion progression in a mouse model of induced white matter stroke longitudinally for 4 months.
Results: We were able to measure persistent, differential changes in DTI parameters in white matter lesions longitudinally, allowing for correlation with ex vivo spatial transcriptomic data.
Impact: Characterization of MRI biomarkers of progression of white matter lesions combined with insight into cellular processes by spatial transcriptomics in this mouse model will allow for better evaluation of treatment candidates for white matter stroke and vascular dementia.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords