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Abstract #4020

Tumor membrane-camouflaged mesoporous polydopamine nanoparticles loaded with Fe(Ⅲ) and ICG for MRI-guided photothermal treatment of glioma

Ping Liu1, Qunhui Ouyang1, and Guihua Jiang1
1Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China

Synopsis

Keywords: Probes & Targets, Molecular Imaging, glioma

Motivation: Advanced theranostic nanoagents for imaging-guided photothermal therapy (PTT) can enhance therapeutic efficacy and enable precise treatment of glioma.

Goal(s): To develop a tumor cell membrane (CM)-camouflaged theranostic nanoagent , enabling photothermal imaging (PI) and MR dual-modal imaging -guided glioblastoma therapy.

Approach: MPDA was firstly chelated with ferric ion (Fe3+), and then loaded with ICG via electrostatic/hydrophobic interactions. Finally, the MPDA-Fe3+-ICG NPs was coated with C6 glioma CM.

Results: NPs exhibited superior photothermal and MR imaging performance, its T1 relativity (r1 = 25.6 mM−1S−1) is approximately 6 folders of the commercial Gd-DTPA. Endowing PI/MRI dual-modal imaging -guided remarkable therapeutic efficiency and minimal side effects.

Impact: This study illustrates that the highly integrated and biocompatible MPDA-based NPs can serve as a versatile nanoplatform by loading different imaging molecules and drugs for multi-modal imaging and cancer combination therapy.

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