Keywords: Molecular Imaging, Molecular Imaging, Ultra Small Lung Metastases, Magnetic Resonance Imaging
Motivation: Pulmonary metastasis is a major cause of cancer-related mortality, with the detection of ultra-small metastatic lesions remaining a significant challenge.
Goal(s): This study aims to develop an innovative MRI contrast agent (CaCO3@quercetin-Mn nanoparticles, CQM NPs) for the early detection and therapeutic intervention of pulmonary metastasis via macrophage-mediated delivery.
Approach: CQM NPs were designed to polarize and direct macrophages to metastatic sites, enabling precise and effective delivery to pulmonary metastases.
Results: The CQM NPs enabled MRI detection of pulmonary metastases as small as 0.23 mm and demonstrated robust inhibitory and prophylactic effects against metastatic lung tumors.
Impact: CQM NPs serve as a promising MRI contrast agent for early detection and as a potential therapeutic option for pulmonary metastasis, offering hope for reducing the high mortality associated with this challenging disease.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords