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Abstract #4021

Nanoparticles capable of navigating macrophages to tumors for magnetic resonance imaging and treatment of ultra small pulmonary metastasis

Meiju Sui1, Yingying Luo1, Sha Li1, Sen Yue1, Daiqin Chen1, Shizhen Chen1, and Xin Zhou1
1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China

Synopsis

Keywords: Molecular Imaging, Molecular Imaging, Ultra Small Lung Metastases, Magnetic Resonance Imaging

Motivation: Pulmonary metastasis is a major cause of cancer-related mortality, with the detection of ultra-small metastatic lesions remaining a significant challenge.

Goal(s): This study aims to develop an innovative MRI contrast agent (CaCO3@quercetin-Mn nanoparticles, CQM NPs) for the early detection and therapeutic intervention of pulmonary metastasis via macrophage-mediated delivery.

Approach: CQM NPs were designed to polarize and direct macrophages to metastatic sites, enabling precise and effective delivery to pulmonary metastases.

Results: The CQM NPs enabled MRI detection of pulmonary metastases as small as 0.23 mm and demonstrated robust inhibitory and prophylactic effects against metastatic lung tumors.

Impact: CQM NPs serve as a promising MRI contrast agent for early detection and as a potential therapeutic option for pulmonary metastasis, offering hope for reducing the high mortality associated with this challenging disease.

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