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Abstract #4022

Evaluation of hypoxia targeting MRI contrast agent FOBNI in brain tumor models at 3T

Maheshwaran Duraiyarasu1, Lakshmisree Damodaran1, Shivani Mantri2, C. Chad Quarles3, and Vikram D. Kodibagkar2
1School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States, 2Arizona State University, Tempe, AZ, United States, 3The University of Texas (UT) MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Keywords: Contrast Agents, Tumors

Motivation: Gadolinium based contrast agents have some disadvantages such as deposition in the kidney, brain etc., We developed biocompatible iron based contrast agent for tumor hypoxia imaging.

Goal(s): Evaluation of FOBNI, an iron based hypoxia targeting contrast agent in brain tumor

Approach: The relaxivities of FOBNI were studied at 3, 7, and 9.4 T fields. Further, a group of three rats with brain tumors underwent dynamic imaging with multiple echo scans with FOBNI.

Results: It showed a clear contrast between normal and hypoxic conditions in solution. The percentage signal enhancements in the tumor over 2 hours were analyzed and showed good results.

Impact: The contrast agent FOBNI showed good hypoxia-targeting ability in rat tumors. This will open a new path to developing iron-based hypoxia-targeting agents as an alternative to traditional gadolinium-based contrast agents.

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Keywords