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Abstract #4023

Lymph Node Suppression with Simultaneous Vascular Suppression on Ferumoxytol-Enhanced Magnetic Resonance Neurography

Shayna Ellie Turbin1, Darryl B Sneag1, Allison Sydney Lowe1, Mylinh Duong2, and Ek Tsoon Tan1
1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 2Pharmacy, Hospital for Special Surgery, New York, NY, United States

Synopsis

Keywords: Contrast Agents, Neurography, USPIO, Lymph Node

Motivation: Ferumoxytol provides vascular suppression in magnetic resonance neurography (MRN), but its effectiveness for lymph node suppression in MRN has not been quantified.

Goal(s): To determine the optimal time and extent of lymph suppression achievable with a low-dose Ferumoxytol infusion for MRN.

Approach: Two healthy subjects were imaged over a 50-hour post-infusion interval to determine the optimal time for MRN. Eight subjects were imaged to quantify lymph node suppression at the optimal time.

Results: Immediately post-infusion (<1 hour), no significant differences were observed between nerve-to-muscle and lymph node-to-muscle contrast ratios. However, at the optimal 15 hours post-infusion, lymph node-to-muscle contrast ratios were significantly reduced.

Impact: Low-dose Ferumoxytol provides significant lymph node suppression and simultaneous vascular suppression in brachial plexus magnetic resonance neurography (MRN) 15 hours post-infusion. Lymph suppression may enable 3D rendering to improve nerve visualization in diagnostic and surgical planning applications.

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Keywords