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Abstract #4026

Ferumoxytol MRI for the Detection of Brain Arteriovenous Malformations Lesions in Patients with Hereditary Hemorrhagic Telangiectasia

Alex Gill1, Emma Benech1, Yoo Jin Lee1, Michael Ohliger1, Jing Liu1, Miles Conrad1, Daniel Langston1, Lindsay Park2, Torianna Lomax Truong1, Janine Lupo1, David Saloner1, and Steven W. Hetts3
1Radiology, UCSF, San Francisco, CA, United States, 2UCSF, San Francisco, CA, United States, 3Radiology and Neurosurgery, UCSF, San Francisco, CA, United States

Synopsis

Keywords: Blood Vessels, Rare disease

Motivation: Patients with Hereditary Hemorrhagic Telangiectasia (HHT) have a high likelihood of developing brain AVMs. Guidelines recommend MRI/MRA screening in childhood and adulthood. As part of a novel head-to-abdomen ferumoxytol-enhanced 3T MRI/MRA (FeMR) protocol, we evaluated sensitivity of FeMR for brain AVMs.

Goal(s): Develop a FeMR exam to screen for brain AVMs. Compare this protocol to gold-standard x-ray digital subtraction catheter angiograms (DSA).

Approach: Conduct 3T FeMR VIBE imaging at multiple resolutions and compare to previously acquired clinical imaging.

Results: 0.8mm isotropic resolution has favorable features. All known brain AVMs (detected via noninvasive gadolinium-enhanced 3T MRI and invasive DSA) were detected by 3T FeMR.

Impact: The AVIATOR study will enable efficient screening and high-resolution non-invasive follow-up of HHT patients. Quantitative MR techniques may be less subject to inter-operator-dependency, thus providing more objective means for developing a global HHT disease burden score.

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Keywords