Abstract #4029

Initial Experience with Non-contrast, Gadolinium, and Ferumoxytol-enhanced Image-based Navigator 3D MRA of the Thoracic Aorta at 0.55T

Juliet Varghese¹, Katherine Binzel^2,3, Syed Murtaza Arshad¹, Ning Jin⁴, Karl P. Kunze⁵, René M. Botnar^6,7, Claudia M. Prieto^6,7, Rizwan Ahmad¹, Yuchi Han⁸, Matthew S. Tong⁸, and Orlando P. Simonetti^3,8

¹Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ²Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States, ³Department of Radiology, The Ohio State University, Columbus, OH, United States, ⁴Siemens Medical Solutions USA, Inc, Malvern, PA, United States, ⁵Siemens Healthineers GmbH, Frimley, United Kingdom, ⁶School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁷Escuela de Ingeniería, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁸Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States

Synopsis

Keywords: Vascular/Vessel Wall, Blood vessels, MR angiography, ferumoxytol, gadolinium contrast

Motivation: The advantages of image-based navigator (iNAV) 3D MRA are its free-breathing capabilities with non-rigid motion correction and predictable acquisition times, leading to reliable performance in patients.

Goal(s): To demonstrate the feasibility of non-contrast and contrast enhanced image-based navigator 3D MRA on a commercial 0.55T system.

Approach: T2 prepared non-contrast enhanced and slow infusion gadolinium contrast enhanced iNAV 3D MRA images were acquired in three volunteers, and ferumoxytol enhanced iNAV 3D MRA in four other volunteers.

Results: Diagnostic image quality was demonstrated for all techniques, illustrating the potential for patient-specific clinical applications at 0.55T.

Impact: The availability of a fixed acquisition time, non-contrast enhanced and contrast-enhanced image-based navigator (iNAV) 3D MRA applications on a commercial 0.55T system can meet patient-specific needs for thoracic aortic angiogram evaluation.

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