Keywords: Diffusion Modeling, Diffusion Modeling, Gray Matter, Microstructure, Soma
Motivation: Biophysical model of diffusion MRI has shown potential for capturing cellular characteristics and pathological conditions in gray matter but has limitations due to the partial volume effect around free water.
Goal(s): To improve the current Soma and Neurite Density Imaging (SANDI) model by incorporating a free-water component that differentiates extracellular space from free water, providing accurate measurements of microstructural properties.
Approach: We implemented the Free-Water-Eliminated (FWE)-SANDI model and validated its performance through noise propagation and in vivo high-gradient diffusion MRI data.
Results: The FWE-SANDI shows consistently estimated soma density in line with standard SANDI while distinguishing between extracellular and free water components.
Impact: The proposed Free-Water-Eliminated (FWE)-SANDI model reduces the partial volume effect from free water and improves the accuracy of non-invasive microstructural imaging in the brain gray matter, allowing ones to better study underlying mechanisms of cellular changes in neurodevelopment and neurodegeneration.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords