Keywords: Simulation/Validation, Simulation/Validation, Myelin water, axon diameter, diffusion
Motivation: Probing diffusion in myelin water using diffusion-weighted T1-/T2-selective MRI acquisitions enables to non-invasively measure myelinated axon radius. Its application for in vivo measurements requires validation through diffusion simulations.
Goal(s): To propose the theory of myelin water diffusion in wide-gradient-pulse sequence and validate its applicability to axon radius estimation via Monte Carlo simulations.
Approach: We derived the theory using Gaussian-phase-approximation. We validated the proposed model by performing diffusion simulations in infinitely thin cylindrical surfaces or concentric cylindrical layers of finite thickness.
Results: Simulation results validated the theory of myelin water diffusivity and axon radius estimation using spherical-mean signals.
Impact: Measuring restricted diffusion of myelin water in-between myelin sheaths using diffusion MRI enables to in vivo measure axon radius. Simulation results demonstrated its applicability at SNR≥5 on Connectome 2.0 scanner. The protocol can be adapted for clinically available high-gradient-performance scanners.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords