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Abstract #4044

Validation of MRI diffusion models using synchrotron radiation imaging in custom microstructural phantoms

Alessandra Maiuro1,2, Michela Fratini3,4, Lorenzo Massimi3, Silvia Cipiccia5, Shashidhara Marathe6, Darren Batey6, Fenglei Zhou5,7, Geoff JM Parker5,8, Silvia Capuani1,2, and Marco Palombo9,10
1Physics, Sapienza University of Rome, Rome, Italy, 2Institute of Complex Systems (CNR-ISC), National Research Council, ROMA, Italy, 3Institute of Nanotechnology (CNR-Nanotec), National Research Council, ROMA, Italy, 4NaN LAboratory, IRCCS Santa Lucia Foundation, Rome, Italy, 5Department of Medical Physics and Biomedical Engineering, Malet Place Engineering, University College London, London, United Kingdom, 6Diamond Light Source,Harwell Science and Innovation Campus, Didcot, United Kingdom, 7MicroPhantoms Ltd., Cambridge, United Kingdom, 8Bioxydyn Limited, Manchester, United Kingdom, 9Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom, 10School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: Simulation/Validation, Diffusion Analysis and Visualization, Microstructure, brain-phantom, validation, synchrotron

Motivation: Diffusion MRI (dMRI) has been traditionally validated by 2D-histochemistry; Synchrotron X-ray phase contrast tomography (XPCT) has provided high resolution images that might be used for more accurate validation.

Goal(s): Our aim is to show the impact of validating dMRI using XPCT.

Approach: A brain-mimicking phantoms was acquired by dMRI and XPCT. In dMRI, diffusion time-dependent data were used to estimate fiber calibres RMR and disorder correlation length lc. In XPCT, the same quantities (RXPCTMR,aXPCT) were calculated from the distribution of fibers’ diameters.

Results: We obtained values RMR=(6.9±0.1)μm and lc~(8.5±0.2)μm, comparable to RXPCTMR=7.86μm and aXPCT=13.0μm.

Impact: A multi-scale approach based on XPCT has been proposed for validating dMRI models applied on DW data obtained on brain-mimicking phantoms. The agreement between dMRI and XPCTresults pave the way for new possibilities of dMRI validation in ex-vivo brain samples.

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Keywords