Keywords: Simulation/Validation, Diffusion Analysis and Visualization, Microstructure, brain-phantom, validation, synchrotron
Motivation: Diffusion MRI (dMRI) has been traditionally validated by 2D-histochemistry; Synchrotron X-ray phase contrast tomography (XPCT) has provided high resolution images that might be used for more accurate validation.
Goal(s): Our aim is to show the impact of validating dMRI using XPCT.
Approach: A brain-mimicking phantoms was acquired by dMRI and XPCT. In dMRI, diffusion time-dependent data were used to estimate fiber calibres RMR and disorder correlation length lc. In XPCT, the same quantities (RXPCTMR,aXPCT) were calculated from the distribution of fibers’ diameters.
Results: We obtained values RMR=(6.9±0.1)μm and lc~(8.5±0.2)μm, comparable to RXPCTMR=7.86μm and aXPCT=13.0μm.
Impact: A multi-scale approach based on XPCT has been proposed for validating dMRI models applied on DW data obtained on brain-mimicking phantoms. The agreement between dMRI and XPCTresults pave the way for new possibilities of dMRI validation in ex-vivo brain samples.
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