Keywords: Spinal Cord, Multiple Sclerosis
Motivation: Lumbar spinal cord diffusion tensor imaging (DTI) could provide insight into lower extremity dysfunction in multiple sclerosis; however, susceptibility artifacts and geometric distortions cause challenges.
Goal(s): Our goal was to deploy a multi-shot, reduced field-of-view, 2D-navigated DTI sequence in the lumbar enlargement to compare healthy and multiple sclerosis findings.
Approach: 28 healthy controls and 35 multiple sclerosis patients were imaged, and difference in DTI indices were explored both within-subject and between-subject.
Results: Significant DTI lesion and white matter differences were found between healthy controls and multiple sclerosis patients, and heterogeneity in DTI indices was found throughout the healthy lumbar spinal cord.
Impact: Evaluation of multi-shot, reduced field-of-view, 2D-navigated DTI of the lumbar spinal cord of healthy volunteers and multiple sclerosis patients provides a unique way to study tissue heterogeneity, and identifying specific lesion locations is necessary to evaluate disease-related damage.
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