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Abstract #4071

Estimate the effects of imaging gradients and gradient miscalibration on the b-matrix using an isotropic diffusion phantom

Ruifeng Dong1, Alan Seth Barnett1, John Andrew Derbyshire2, and Carlo Pierpaoli1
1Laboratory on Quantitative Medical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, United States, 2Functional MRI Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

Synopsis

Keywords: Diffusion Modeling, Diffusion Modeling, b-matrix, imaging gradients, gradient miscalibration

Motivation: To achieve “harmonized” multi-site diffusion MRI (dMRI) results, it is important to account for differences in diffusion sensitization across scanners caused by imaging gradients and gradient miscalibration.

Goal(s): To use a dMRI dataset on an isotropic phantom to measure the effects of imaging gradients and gradient miscalibration and correct both effects on another dMRI dataset.

Approach: Use a mathematical model of b-matrix to fit contributions of imaging gradients and gradient miscalibration to a multi-shell dMRI dataset.

Results: Our correction reduced the $$$\chi^2$$$ error in fitting test data, relative error in diffusivity, artifactually high fractional anisotropy by a factor of 21, 2, 6, respectively.

Impact: Our method can be used to account for the effects of imaging gradients and gradient miscalibration on different scanners and sites and should help harmonizing multi-site diffusion MRI data.

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Keywords