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Abstract #4077

Rapid Mesoscopic Resolution DTI with High-Performance 7T

Yi-Hang Tung1, Hendrik Mattern1,2,3, and Oliver Speck1,2,3,4
1Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany, 2German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany, 3Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany, 4Leibniz Institute for Neurobiology (LIN), Magdeburg, Germany

Synopsis

Keywords: Diffusion Acquisition, Brain, DTI, mesoscopic, ultrahigh field

Motivation: Diffusion tensor imaging (DTI) typically requires multiple signal averaging to mitigate low signal strength, posing a challenge for rapid DTI, especially when high spatial resolutions is desired.

Goal(s): This study targets a DTI resolution of 0.5 mm in-plane with the shortest possible scan time.

Approach: Averaging at different resolutions on a high-performance 7T scanner and denoising were utilized for fast and high-quality DTI.

Results: Mesoscopic resolution DTI with 0.5 mm resolution is possible within 10 minutes; adding denoising reduces scan time to 3 minutes.

Impact: Fast and high-quality DTI with mesoscopic in-plane resolution (0.5 mm) is possible on a high-performance human 7T scanner within 3 minutes. The protocol can screen the entire brain swiftly for pathological tissues.

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