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Abstract #4092

Elevated Apparent Diffusion Coefficient of Water in Extra-axial Space following Acute Head Injury

Sophia Z. Cheng1, Nicole Peterkin1, Marie Luby1, L. Christine Turtzo1, and Lawrence L. Latour1
1Acute Cerebrovascular Diagnostics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

Synopsis

Keywords: Diffusion Analysis & Visualization, Diffusion Analysis and Visualization, Traumatic Brain Injury

Motivation: The apparent diffusion coefficient (ADC) of water in extra-axial space in patients following acute traumatic brain injury (TBI) can be elevated above the ADC of free water, warranting further study of this phenomenon.

Goal(s): To explore ADC dynamics in the extra-axial space of acute TBI patients.

Approach: Suspected TBI patients (n=52) with and without traumatic meningeal enhancement (TME) were assessed for elevated ADC in extra-axial space across time.

Results: TME patients had elevated ADC values in regions of TME compared to ADC values in the extra-axial space of patients without TME. Baseline elevated ADC predicted TME at 1-week follow-up (p<0.001).

Impact: Clinical diffusion imaging may be used to detect TME and predict TME at follow-up without the need for contrast administration, suggesting diagnostic utility for acute TBI patients.The contribution of flow to elevated ADC values will be further explored.

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Keywords