Keywords: Diffusion Analysis & Visualization, Diffusion Analysis and Visualization, Traumatic Brain Injury
Motivation: The apparent diffusion coefficient (ADC) of water in extra-axial space in patients following acute traumatic brain injury (TBI) can be elevated above the ADC of free water, warranting further study of this phenomenon.
Goal(s): To explore ADC dynamics in the extra-axial space of acute TBI patients.
Approach: Suspected TBI patients (n=52) with and without traumatic meningeal enhancement (TME) were assessed for elevated ADC in extra-axial space across time.
Results: TME patients had elevated ADC values in regions of TME compared to ADC values in the extra-axial space of patients without TME. Baseline elevated ADC predicted TME at 1-week follow-up (p<0.001).
Impact: Clinical diffusion imaging may be used to detect TME and predict TME at follow-up without the need for contrast administration, suggesting diagnostic utility for acute TBI patients.The contribution of flow to elevated ADC values will be further explored.
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