Keywords: Psychiatric Disorders, Psychiatric Disorders, DTI
Motivation: Investigating microstructural changes at the subfield level in patients with schizophrenia (SCZ) could enhance our understanding of the disease and inform precision medicine approaches.
Goal(s): To investigate diffusion anisotropy alterations in hippocampal subfields of SCZ patients using submillimeter whole-brain DTI.
Approach: SCZ patients and healthy controls (HC) underwent MRI scans. Sixteen hippocampal subfields were segmented, with quantitative diffusion parameters extracted for each subfield and compared between SCZ and HC.
Results: Compared to HC, SCZ patients exhibited altered diffusion parameters in 9 hippocampal subfields. Notably, some of these alterations correlated with cognitive impairment.
Impact: The observed hippocampal anisotropy alterations may serve as sensitive imaging biomarkers for schizophrenia, potentially associated with cognitive impairment. These findings offer a promising foundation for further exploration of targeted clinical interventions in SCZ patients.
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