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Abstract #4096

Submillimeter whole-brain diffusion tensor imaging reveals diffusion anisotropy alterations in hippocampal subfields of schizophrenia

Kunxuan Wang1,2, Yuan Sun3, Huilou Liang4, Na Hu1,2, and Su Lui1,2
1Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China, 3Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 4GE Healthcare MR Research, Beijing, China

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, DTI

Motivation: Investigating microstructural changes at the subfield level in patients with schizophrenia (SCZ) could enhance our understanding of the disease and inform precision medicine approaches.

Goal(s): To investigate diffusion anisotropy alterations in hippocampal subfields of SCZ patients using submillimeter whole-brain DTI.

Approach: SCZ patients and healthy controls (HC) underwent MRI scans. Sixteen hippocampal subfields were segmented, with quantitative diffusion parameters extracted for each subfield and compared between SCZ and HC.

Results: Compared to HC, SCZ patients exhibited altered diffusion parameters in 9 hippocampal subfields. Notably, some of these alterations correlated with cognitive impairment.

Impact: The observed hippocampal anisotropy alterations may serve as sensitive imaging biomarkers for schizophrenia, potentially associated with cognitive impairment. These findings offer a promising foundation for further exploration of targeted clinical interventions in SCZ patients.

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