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Abstract #4097

Evidence of lower myelin content in selective white matter tracts of OCD children/adolescents using a myelin water imaging approach

Jeffrey A. Stanley1, Jennifer Losiowski2, Phillip Easter1, Dalal Khatib1, Pamela Szura1, Rebecca Neill1, Usha Rajan1, Julia Bellamy1, David R. Rosenberg1, and Vaibhav A. Diwadkar1
1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, 2Wayne State University School of Medicine, Detroit, MI, United States

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders

Motivation: White matter tracts have been implicated in pediatric OCD by DTI studies; however, the interpretation of DTI-derived indices regarding attributes of WM microstructure is limited and poorly understood.

Goal(s): To identify group differences and age effects on MWI metrics (MWF and geomT2IEW) across WM tracts in pediatric OCD compared to controls.

Approach: MWF and geomT2IEW across 5 WM tracts were assessed in 33 OCD and 58 HC.

Results: Significantly lower myelin content was observed in association fibers in OCD compared to HC. Age effects were observed for MWF in projection/association fibers reflecting a lack of progressive increasing MWF values with age in OCD.

Impact: Compared to healthy individuals, OCD children/adolescents show deficits in myelin content in association fibers, as well as evidence suggesting a lack of progressive maturation of both (anterior) projection and association fibers in pediatric OCD, which warrants longitudinal studies.

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Keywords