Keywords: Psychiatric Disorders, Psychiatric Disorders
Motivation: White matter tracts have been implicated in pediatric OCD by DTI studies; however, the interpretation of DTI-derived indices regarding attributes of WM microstructure is limited and poorly understood.
Goal(s): To identify group differences and age effects on MWI metrics (MWF and geomT2IEW) across WM tracts in pediatric OCD compared to controls.
Approach: MWF and geomT2IEW across 5 WM tracts were assessed in 33 OCD and 58 HC.
Results: Significantly lower myelin content was observed in association fibers in OCD compared to HC. Age effects were observed for MWF in projection/association fibers reflecting a lack of progressive increasing MWF values with age in OCD.
Impact: Compared to healthy individuals, OCD children/adolescents show deficits in myelin content in association fibers, as well as evidence suggesting a lack of progressive maturation of both (anterior) projection and association fibers in pediatric OCD, which warrants longitudinal studies.
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