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Abstract #4103

Reduced fMRI-complexity in pre-adolescent children with comorbid-free and comorbid ADHD, ODD, and OCD diagnoses

Ru Zhang1, Cen Steven1, Dilmini Wijesinghe1, Leon Aksman1, Stuart Murray2, Christina Duval3, Danny Wang1, and Kay Jann1
1University of Southern California, Los Angeles, CA, United States, 2University of California, Los Angeles, Los Angeles, CA, United States, 3St. Louis University, St. Louis, MO, United States

Synopsis

Keywords: Psychiatric Disorders, fMRI (resting state), Complexity analysis, ADHD

Motivation: Previous studies have shown reduced resting-state fMRI (rsfMRI)-complexity in attention-deficit/hyperactivity disorder (ADHD). However, the impact of comorbidity remains unclear.

Goal(s): To investigate rsfMRI-complexity in ADHD, oppositional defiant disorder (ODD), and obsessive-compulsive disorder (OCD) for both comorbid-free and comorbid presentations.

Approach: Hierarchical models with Generalized Estimating Equations compared sample entropy within executive function networks of pre-adolescents with comorbid-free and comorbid ADHD, ODD, and OCD.

Results: RsfMRI-complexity was reduced in more regions in ADHD than in ODD compared to healthy controls in the comorbid-free presentations. In comorbidity, ADHD dominated complexity reduction. OCD had no significant impact on complexity in either scenario.

Impact: Resting-state fMRI-complexity for ADHD comorbidity remains poorly understood, although reduced complexity in ADHD was reported. Our study demonstrates reduced complexity in ADHD pre-adolescents, both in comorbid-free cases and in those comorbid with oppositional defiant disorder, obsessive-compulsive disorder, and other conditions.

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