Abstract #4111

Molecular Mechanisms Underlying NAA and FDG Uptake Coupling in Temporal Lobe Epilepsy: Insights from Imaging Transcriptomics

Jiwei Li¹, Longfei Zhao¹, Hui Huang¹, Yibo Zhao², Yudu Li^2,3,4, Wen Jin^2,5, Bingyang Cai¹, Haiqing Zhang¹, Miao Zhang⁶, Zhi‑Pei Liang^2,5, and Jie Luo¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States, ³Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁴National Center for Supercomputing Applications, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁵Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁶Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

Keywords: Epilepsy, Epilepsy

Motivation: The underlying mechanism between the coupling of neuronal marker N-acetyl aspartate (NAA) and glucose uptake in temporal lobe epilepsy (TLE) remains unclear.

Goal(s): We aim to investigate molecular underpinnings of NAA and FDG correlations.

Approach: Patients with drug resistant temporal lobe epilepsy underwent simultaneous high resolution whole-brain PET/MRSI. With processed NAA/Cr maps and FDG SUVR, we evaluated metabolic coupling across brain regions and identified cell types and pathways linked to these metabolic changes.

Results: Our results revealed significant correlations between NAA and FDG in TLE-affected regions. Gene enrichment analysis further highlighted excitatory neuron involvement in TLE-related metabolic coupling.

Impact: This study provides insight into the molecular basis of metabolic coupling in temporal lobe epilepsy, specifically examining the relationship between NAA levels and FDG uptake. The findings may shed new light on epileptogenesis and potential therapeutic targets.

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