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Abstract #4112

Parallel transmit 7T MRI improves epileptogenic lesion detection compared to circularly polarized 7T MRI

Krzysztof Klodowski1, Minghao Zhang1, Daniel Scoffings2, Jian P. Jen2, Thomas E. Cope2,3,4,5, and Christopher T. Rodgers1,5
1Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, 2Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 3MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom, 4Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 5Joint Senior Authors, ., United Kingdom

Synopsis

Keywords: Epilepsy, Epilepsy, ptx, 7T

Motivation: 7T MRI offers high sensitivity and sub-millimetre resolution which may be valuable for pre-surgical assessment of drug-resistant focal epilepsy (DRFE) patients. Yet single transmit studies have been limited by signal-dropouts especially in temporal lobes.

Goal(s): To assess whether parallel transmit (7T-pTx) MRI improves the diagnostic quality of the ILAE 7T Epilepsy Task Force Consensus Recommended protocols.

Approach: Prospective study of 31 adult DRFE patients whose prior 3T MRI was inconclusive scanned with pTx and CP 7T MRI.

Results: Detection of new lesions in 29% of cases. Neuroradiologists report better quality for pTx acquisitions which is supported by quantitative metrices.

Impact: This study confirms that 7T-pTx MRI is more effective for detection of lesions in drug-resistant focal epilepsy patients than CP 7T MRI. We are now seeking funding for a multisite study to prove cost-effectiveness within the NHS epilepsy surgery pathway.

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