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Abstract #4123

Investigating Neurochemical Alterations in Tuberous Sclerosis Complex (TSC) Using 2D Multi-slice MRSI at 3T

Dillip K. Senapati1, Helge J. Zöllner2, İpek Özdemir2, Peter B. Barker2,3, and Doris Lin2
1Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Epilepsy, Spectroscopy, Spectroscopic Imaging(MRSI), Epilepsy, Tuberous Sclerosis Complex(TSC), Metabolism

Motivation: There are relatively few prior studies investigating brain metabolites in Tuberous Sclerosis Complex (TSC), mostly using single voxel localization that were limited to a few selected brain areas.

Goal(s): To characterize brain metabolite alterations in patients with TSC that may be the underpinning of neurologic and neuropsychological manifestations.

Approach: Multi-slice 2D-MRSI was used to estimate metabolites in cortical/subcortical tubers and normal appearing brain regions in TSC patients, and compared to healthy controls (HC).

Results: TSC subjects show significant metabolic abnormalities (elevation of mI/tCr, reduced tCho/tCr and tNAA/tCr) compared to HC, both in brain regions with normal MRI appearance as well as in tubers.

Impact: These findings may help to understand the underlying pathogenesis of brain involvement in TSC, including their relationships to neurological symptoms and cognitive impairment.

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