Keywords: Heart Failure, Heart Failure, Heart failure with preserved ejection fraction, cardiac magnetic resonance, strain, left atrium, prognosis
Motivation: LA booster function plays a critical role in the progression of HFpEF.
Goal(s): To evaluate the prognostic value of a novel strain-derived index—LA contractile index in patients with HFpEF.
Approach: This retrospective study included 803 patients. The primary endpoint was a composite of cardiovascular death and HF hospitalization. LA contractile index was calculated as the percentage of booster strain relative to reservoir strain.
Results: Over a median follow-up of 7.3 years, the abnormal LA contractile index was independently associated with the primary endpoint. The models incorporating clinical, conventional imaging variables, and LA contractile index exhibited the highest calibration.
Impact: A novel index derived from CMR-FT—LA contractile index shows its potential as a robust predictor of adverse outcomes in patients with HFpEF, providing novel insights into the pathophysiology and prognostication of this condition.
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