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Abstract #4159

Novel Insights into Left Atrial Mechanics: Prognostic Value of Left Atrial Contractile Index in Heart Failure with Preserved Ejection Fraction

Leyi Zhu1, Jian He1, Jing Xu1, Wenjing Yang1, Shihua Zhao1, and Minjie Lu1
1Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Synopsis

Keywords: Heart Failure, Heart Failure, Heart failure with preserved ejection fraction, cardiac magnetic resonance, strain, left atrium, prognosis

Motivation: LA booster function plays a critical role in the progression of HFpEF.

Goal(s): To evaluate the prognostic value of a novel strain-derived index—LA contractile index in patients with HFpEF.

Approach: This retrospective study included 803 patients. The primary endpoint was a composite of cardiovascular death and HF hospitalization. LA contractile index was calculated as the percentage of booster strain relative to reservoir strain.

Results: Over a median follow-up of 7.3 years, the abnormal LA contractile index was independently associated with the primary endpoint. The models incorporating clinical, conventional imaging variables, and LA contractile index exhibited the highest calibration.

Impact: A novel index derived from CMR-FT—LA contractile index shows its potential as a robust predictor of adverse outcomes in patients with HFpEF, providing novel insights into the pathophysiology and prognostication of this condition.

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