Abstract #4161

Association of right ventricular structure and function with Heart Failure with reduced and preserved Ejection Fraction: the MESA study

Bharath Ambale Venkatesh¹, Monica Mukherjee¹, Ashkan Abdollahi¹, Omar Chehab¹, Ralph Zeitoun¹, Vinithra Varadarajan¹, Colin Wu², Graham Barr³, Wendy Post¹, Norrina Allen⁴, Steven Kawut⁵, David Bluemke⁶, and Joao Lima¹

¹Johns Hopkins University, Baltimore, MD, United States, ²NIH, Bethesda, MD, United States, ³Columbia University, New York, NY, United States, ⁴Northwestern University, Chicago, IL, United States, ⁵University of Pennsylvania, Philadelphia, PA, United States, ⁶University of Wisconsin, Madison, WI, United States

Synopsis

Keywords: Heart Failure, Heart Failure, Right ventricle

Motivation: The right side of the heart has been less studied compared to the left side in its association with heart failure.

Goal(s): To study the association of right ventricular structure and function with incident Heart Failure subtypes.

Approach: We assess the association of right ventricular structure and function measured by cardiac magnetic resonance to incident heart failure subtypes in a large multi-ethnic cohort free of cardiovascular disease.

Results: In this large cohort study, low right ventricular ejection fraction was predictive of Heart Failure with reduced Ejection Fraction while very high right ventricular ejection fraction was predictive of Heart Failure with preserved Ejection Fraction.

Impact: We have identified a subset of individuals with a unique phenotype of supernormal RV ejection fraction that may be at a higher risk of heart failure with preserved ejection fraction.

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