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Abstract #4184

Quantitative Characterization of Myocardial Reperfusion Injury via Push-Button Delayed-Phase Dynamic Contrast-Enhanced (dDCE) MRI

Xinheng Zhang1, Li-Ting Huang2, Hsin-Jung Yang2, and Xinqi Li2,3
1BIRI, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany

Synopsis

Keywords: Myocardium, Tissue Characterization, Dynamic Contrast-Enhanced MRI, Myocardial Infarction, Low-Rank Tensor Framework

Motivation: A quantitative tool to characterize tissue composition and microvascular integrity is
desired for assessing post-MI tissue injury and guide the management of acute
myocardial infarction.

Goal(s): Develop a clinically viable method using a delayed-phase dynamic contrast
enhancement (dDCE) model for quantitative assessment of myocardial injury post-MI.

Approach: A free-running with a low-rank tensor (LRT) framework was developed to enable whole-heart quantitative contrast dynamic imaging during contrast washout. Combined with DCE model, physiological parameters were derived to assess myocardial injury.

Results: The 3D LRT-dDCE maps correlated well with conventional 2D breath-hold methods,
identifying abnormal microvascular permeability and increased extracellular volume in
the MI zone.

Impact: LRT-dDCE demonstrated the potential of a clinically viable sequence to quantitativelyassess myocardial injury. The dDCE parameters can potentially provide detailedinsights post-ischemic impact and during tissue healing.

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Keywords