Abstract #4204

Fixel-based analysis of white matter fiber characteristics and cognitive dysfunction in Alzheimer’s disease

Wenxuan Li^1,2, Ting Huang³, Rong Liu³, Jianbing Zhu^4,5, Shangxian Xu⁶, Jianliang Wang⁷, Ping Wang⁸, Xiaoyun Liang^9,10, Jiangtao Zhu³, and Lei Zhang^1,2

¹Medical Physics Graduate Program, Duke Kunshan University, Suzhou, China, ²Jiangsu Provincial University Key Laboratory for Smart Diagnosis and Treatment of Lung Cancer, Duke Kunshan University, Suzhou, China, ³Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China, ⁴Department of Radiology, Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School of Nanjing University, Suzhou, China, ⁵Tongan Branch Hospital, Suzhou Hospital, Affiliated Hospital of Medical School of Nanjing University, Suzhou, China, ⁶Department of Anesthesiology, Children's Hospital of Soochow University, Suzhou, China, ⁷Department of Radiology, The First People's Hospital of Kunshan, Suzhou, China, ⁸Neuroimaging Innovation Center in the Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States, ⁹Institute of Artificial Intelligence and Clinical Innovation, Neusoft Medical Systems Co., Ltd., Shanghai, China, ¹⁰Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia

Synopsis

Keywords: DWI/DTI/DKI, Alzheimer's Disease

Motivation: The relationship between white matter (WM) structure, Alzheimer's disease (AD) progression, and cognitive dysfunction remains unclear.

Goal(s): To identify WM fiber differences between healthy controls (HC), mild cognitive impairment (MCI), mild AD, moderate AD, and WM fiber characteristics correlation with cognitive dysfunctions.

Approach: Fixel-based analysis (FBA) was used to measure WM fiber density (FD), fiber cross-sectional area (FC), and fiber density and cross-section (FDC) across 27 HC, 19 MCI, 19 mild AD, and 25 moderate AD participants.

Results: AD patients showed significant reductions in FD, FC, and FDC in various WM fiber tracts. Some of the reductions also correlated with lower cognitive scores.

Impact: This study shows that FBA-measured WM fiber characteristics correlate with AD severity and cognitive decline. These metrics may serve as biomarkers for monitoring disease progression and aiding in the diagnosis of AD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.