Abstract #4205

Q-space Trajectory Imaging with tensor-valued diffusion encoding for clinical usage in temporal lobe epilepsy

Jan Malte Oeschger^1,2, Francisco J. Fritz², Luke J. Edwards³, Markus Nilsson ⁴, Filip Szczepankiewicz⁴, Arthur Chakwizira⁴, Ileana Jelescu⁵, Quentin Uhl⁵, and Siawoosh Mohammadi^1,2,3

¹Institute for Neuroradiology, Lübeck University, Lübeck, Germany, ²Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ³Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁴Department of Medical Radiation Physics, Lund University, Lund, Sweden, ⁵Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland

Synopsis

Keywords: Microstructure, Diffusion Modeling, QTI, free waveform, Epilepsy

Motivation: Drug-resistant temporal lobe epilepsy requires reliable identification of epileptogenic brain regions for surgical planning, here Q-space Trajectory Imaging (QTI) could provide microstructural information complementary to clinical MRI.

Goal(s): Assessing the reproducibility of key QTI parameters (µFA, MKA, MKI) across two distinct protocols to determine future protocol choice.

Approach: Four subjects underwent QTI imaging on a 3T MRI scanner, including one scan-rescan. Two protocols were compared to evaluate variability across subjects, regions, and scan-rescan.

Results: Protocol 2, with higher SNR, showed lower scan-rescan variability, while Protocol 1’s elevated MKI values in certain regions suggested potential false positives, highlighting the need for careful protocol selection.

Impact: This study helps scientists select more reliable QTI diffusion protocols for TLE imaging, possibly enabling more accurate identification of epileptogenic brain regions for surgical intervention. It is demonstrated that small changes in acquisition parameters can significantly impact parameter estimates.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.