Abstract #4212

Sex-specific relationships among risk factors in those with Mild Cognitive Impairment or Alzheimer’s disease and healthy controls

Brittany Intzandt^1,2, Joel Ramirez^1,3,4, Benjamin Lam^5,6, Mario Masellis^1,5,6,7,8, ONDRI Researchers⁹, Christopher JM Scott^1,4,6, Gillian Einstein^10,11,12, Louis Bherer^13,14,15, and Sandra Black^2,4,5,6,8

¹Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, ²The Dr. Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Toronto, ON, Canada, ⁵Faculty of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada, ⁶LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, ON, Canada, ⁷Cognitive and Movement Disorders Clinic, Sunnybrook Health Sciences Center, Toronto, ON, Canada, ⁸Toronto Dementia Research Alliance, Toronto, ON, Canada, ⁹Ontario Brain Institute, Toronto, ON, Canada, ¹⁰Department of Psychology, University of Toronto, Toronto, ON, Canada, ¹¹Rotman Research Institute, Baycrest Hospital, Toronto, ON, Canada, ¹²Linkoping University, Linkoping, Sweden, ¹³Department of Medicine, University of Montreal, Montreal, QC, Canada, ¹⁴Research Center and Centre EPIC, Montreal Heart Institute, Montreal, QC, Canada, ¹⁵Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: The increasing global incidence of dementia, particularly among females, necessitates a deeper understanding of risk factors (RF) to inform healthcare interventions.

Goal(s): This study aims to identify both non-modifiable and modifiable RF for cognitive decline (CD), emphasizing sex-specific differences in these factors and their interrelationships.

Approach: A network analysis of 353 participants from the Sunnybrook Dementia Study and Ontario Neurodegenerative Research Initiative, comparing RF in healthy controls and those with CD, including cerebral structural MRI imaging.

Results: Our findings revealed distinct network patterns of RF, highlighting greater interconnectedness among RF in CD individuals, with notable sex differences, underscoring the need for sex-specific analyses.

Impact: This study identifies sex-specific risk factor networks in cognitive decline, suggesting tailored intervention points. By pinpointing unique biomarkers and relationships, particularly among modifiable factors, these findings advance the path toward precision medicine in dementia care.

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