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Abstract #4224

What occurs in medial temporal lobe atrophy (MTA) in early dementia? Pathological background and the utility of MTA grading

Hiroto Takahashi1, Shuko Takeda2, Yoichi Takami2, Naoki Hayakawa2, Chisato Matsuo1, Atsuko Arisawa1, Azusa Miura1, and Noriyuki Tomiyama1
1Radiology, Osaka University Graduate School of Medicine, Suita, Japan, 2Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan

Synopsis

Keywords: Alzheimer's Disease, biomarkers, medial temporal lobe atrophy, tau pathology

Motivation: A practical method for evaluating early-stage Alzheimer’s disease (AD) such as medial temporal lobe atrophy (MTA) grading has been required.

Goal(s): To clarify the pathological background of MTA and the utility of MTA grading.

Approach: Correlations between MTA scores and each diffusion metric and cerebrospinal flow (CSF) biomarker were statistically analyzed for both AD pathology and non-AD pathology in early dementia.

Results: MTA scores were more correlated with diffusion metrics and CSF biomarkers in AD pathology than in non-AD pathology. MTA grading might be a practical method for assessing both neurodegeneration and severity of tau pathology in early-stage AD.

Impact: MTA grading that reflects both neurodegeneration and severity of tau pathology might be a practical method for evaluating early-stage AD and it can be a predictor for the effect of disease-modifying therapy by assessing the severity of tau pathology.

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Keywords