Keywords: Alzheimer's Disease, biomarkers, medial temporal lobe atrophy, tau pathology
Motivation: A practical method for evaluating early-stage Alzheimer’s disease (AD) such as medial temporal lobe atrophy (MTA) grading has been required.
Goal(s): To clarify the pathological background of MTA and the utility of MTA grading.
Approach: Correlations between MTA scores and each diffusion metric and cerebrospinal flow (CSF) biomarker were statistically analyzed for both AD pathology and non-AD pathology in early dementia.
Results: MTA scores were more correlated with diffusion metrics and CSF biomarkers in AD pathology than in non-AD pathology. MTA grading might be a practical method for assessing both neurodegeneration and severity of tau pathology in early-stage AD.
Impact: MTA grading that reflects both neurodegeneration and severity of tau pathology might be a practical method for evaluating early-stage AD and it can be a predictor for the effect of disease-modifying therapy by assessing the severity of tau pathology.
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