Abstract #4227

Detection of amyloid-related imaging abnormality (ARIA) in Alzheimer’s patients receiving anti-amyloid antibody therapy using long-TE ASL MRI

Zhiyi Hu¹, Chenyang Li², Zihan Wang¹, Li Jiang², Thomas Wisniewski^3,4, Yulin Ge², and Hanzhang Lu^1,5,6

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Center for Biomedical Imaging, New York University Grossman School of Medicine, New York, NY, United States, ³Department of Neurology, Center for Cognitive Neurology, New York University Grossman School of Medicine, New York, NY, United States, ⁴Alzheimer's Disease Research Center, New York University Grossman School of Medicine, New York, NY, United States, ⁵The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: Anti-amyloid antibody therapy has brought excitement to the Alzheimer’s community but the common side-effect of amyloid-related imaging abnormality (ARIA) related to small vessel damage still represents a major caveat.

Goal(s): To conduct early detection of ARIA using long-TE arterial-spin labeling (ASL) MRI.

Approach: Three Alzheimer’s patients were studied. ASL CSF fraction maps were obtained using a long-TE ASL with effective TE (eTE)=480ms. Three healthy volunteers were also studied.

Results: Regions with brain lesions or ARIA-E revealed higher ASL CSF fraction when compared to the rest of the brain. ASL CSF fraction in deep-brain was higher in patients than in controls.

Impact: This study demonstrated the first application of long-TE ASL in AD patients receiving anti-amyloid antibody therapy. The results support the hypothesis that arterial vessels are leaky following anti-amyloid therapy, presumably due to clearance of amyloid beta (Aβ) from vessel walls.

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