Keywords: Alzheimer's Disease, Alzheimer's Disease
Motivation: CEST MRI has potential to image the molecular changes in the brain of Alzheimer’s disease (AD).
Goal(s): Our objective was to evaluate the efficacy of CEST MRI in imaging AD and mild cognitive impairment (MCI) or non-AD dementia patients at 3T.
Approach: CEST MRI scans were conducted for 40 healthy volunteers and 22 MCI/AD/non-AD dementia patients. Other clinical assessments include PET scans to detect the amyloid plaques and Montreal Cognitive Assessment Hong Kong version (HK-MoCA) to evaluate the cognitive function.
Results: CEST revealed significant differences between HC and patient groups and exhibited strong correlations with the HK-MoCA score.
Impact: CEST revealed significant differences between HC and MCI/AD and exhibited strong correlations with the HK-MoCA score. CEST MRI has potential to detect molecular changes in brain, providing additional information for AD diagnosis in clinical MRI settings.
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