Meeting Banner
Abstract #4233

Exploring the potential clinical application of CEST MRI in the diagnosis of Alzheimer's disease

Jiawen Wang1, Huabin Zhang1, Ziyan Wang1, Pei Cai1, Shihao Zeng1, Hui Zhang2, Peng Cao1, Kannie WY CHAN 3, Yat-Fung Shea4, Patrick Ka-Chun Chiu4, Eva YW Cheung1, Henry Ka-Fung Mak1, and Jianpan Huang1
1The University of Hong Kong, Hong Kong, China, 2The Hong Kong Polytechnic University, Hong Kong, China, 3City University of Hong Kong, Hong Kong, China, 4Queen Mary Hospital, Hong Kong, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: CEST MRI has potential to image the molecular changes in the brain of Alzheimer’s disease (AD).

Goal(s): Our objective was to evaluate the efficacy of CEST MRI in imaging AD and mild cognitive impairment (MCI) or non-AD dementia patients at 3T.

Approach: CEST MRI scans were conducted for 40 healthy volunteers and 22 MCI/AD/non-AD dementia patients. Other clinical assessments include PET scans to detect the amyloid plaques and Montreal Cognitive Assessment Hong Kong version (HK-MoCA) to evaluate the cognitive function.

Results: CEST revealed significant differences between HC and patient groups and exhibited strong correlations with the HK-MoCA score.

Impact: CEST revealed significant differences between HC and MCI/AD and exhibited strong correlations with the HK-MoCA score. CEST MRI has potential to detect molecular changes in brain, providing additional information for AD diagnosis in clinical MRI settings.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords