Keywords: RF Arrays & Systems, Brain
Motivation: Hyperpolarization boosts 13C signals by 4-5 orders of magnitude. Cryogenically cooled RF coils can further enhance SNR by reducing noise.
Goal(s): Demonstrate increased sensitivity of cryogenically cooled RF coils for detecting mouse brain metabolism and high-resolution kidney pH imaging.
Approach: Healthy mice received polarized [1-13C] pyruvate and [1,5-13C2]Z_OMPD, imaged with a cryogenically cooled 13C coil using FID-CSI and 3D-bSSFP.
Results: An 5-fold sensitivity increase preclinical hyperpolarized MRI experiments using a cryogenically-cooled RF coil. This enabled high sensitivity detection of CO₂ and bicarbonate in mouse brain and pH distribution in mouse kidney.
Impact: Combining hyperpolarized 13C agents with cryogenically cooled RF coils enhances SNR improving the preclinical imaging setup.
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