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Abstract #4262

Enhanced preclinical metabolic imaging of hyperpolarized 13C nuclei using a cryogenically-cooled transmit-receive RF coil

Luca Nagel1, Martin Gierse2, Stephan Knecht2, Zumrud Ahmadova2, Senay Karaali2, Martin Grashei1, Sandra Sühnel1, Nadine Setzer1, Geoffrey J. Topping1, Ilai Schwartz2, and Franz Schilling1,3
1Technical University of Munich, TUM School of Medicine and Health, Department of Nuclear Medicine, TUM University Hospital, Munich, Germany, 2NVision Imaging Technologies GmbH, Ulm, Germany, 3Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany

Synopsis

Keywords: RF Arrays & Systems, Brain

Motivation: Hyperpolarization boosts 13C signals by 4-5 orders of magnitude. Cryogenically cooled RF coils can further enhance SNR by reducing noise.

Goal(s): Demonstrate increased sensitivity of cryogenically cooled RF coils for detecting mouse brain metabolism and high-resolution kidney pH imaging.

Approach: Healthy mice received polarized [1-13C] pyruvate and [1,5-13C2]Z_OMPD, imaged with a cryogenically cooled 13C coil using FID-CSI and 3D-bSSFP.

Results: An 5-fold sensitivity increase preclinical hyperpolarized MRI experiments using a cryogenically-cooled RF coil. This enabled high sensitivity detection of CO₂ and bicarbonate in mouse brain and pH distribution in mouse kidney.

Impact: Combining hyperpolarized 13C agents with cryogenically cooled RF coils enhances SNR improving the preclinical imaging setup.

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