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Abstract #4328

Free-breathing joint T1-T2 and extracellular volume mapping of the long-term transplanted heart at 3T.

Pauline Calarnou1, Augustin C. Ogier1, Tamila Abdurashidova2, Zélia Donato2, Stéphane Fournier2, Quentin Liabot2, Jean-Baptiste Ledoux1,3, Jérôme Yerly1,3, Roger Hullin2, and Ruud Van Heeswijk1
1Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Cardiology Service, Cardiovascular Department, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3CIBM Center for BioMedical Imaging, Lausanne and Geneva, Switzerland, Lausanne, Switzerland

Synopsis

Keywords: Myocardium, Quantitative Imaging

Motivation: Transplanted hearts face less rejection after a year but still require monitoring for complications; free-breathing, precise parametric mapping may aid this.

Goal(s): To characterize a free-breathing joint T1-T2 cardiac MRI technique named PARMA in long-term heart-transplant recipients.

Approach: We compared PARMA T1, T2 and extracellular volume maps to routine maps as well as quantitative stress perfusion and the X-ray angiography microcirculatory resistance in 39 heart transplant recipients.

Results: Free-breathing parametric mapping was successful in all participants with equivalent or better performance compared to routine techniques, but no correlation was found with quantitative stress perfusion or microcirculatory resistance.

Impact: Transplanted hearts face less rejection after a year but still require monitoring for complications. We therefore demonstrated the feasibility and reference range of free-breathing joint T1-T2 mapping in this patient group.

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