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Abstract #4329

Free-breathing rapid T1 mapping for the dynamic response quantification of contrast-enhanced whole-heart myocardium

Bowei Liu1, Rui Guo2, and Haiyan Ding1
1Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China, 2School of Medical Technology, Beijing Institute of Technology, Beijing, China

Synopsis

Keywords: Myocardium, Myocardium, dynamic T1 mapping, contrast enhancement, free-breathing, whole-heart

Motivation: Early gadolinium enhancement has the potential for myocardial tissue characterization while not yet widely adopted due to the natural of the contrast agent kinetics.

Goal(s): This study aims to develop a Dynamic Approach for Rapid T1 mapping (DART) to quantify the dynamic T1 values with sufficient spatial-temporal resolution and whole heart coverage.

Approach: DART combined dynamic and stable phase into a single free-breathing scan with interleaved slice-tracking multi-slice acquisition. By sharing the equilibrium magnetization estimated from the stable phase, dynamic T1 was calculated.

Results: DART sequence was validated through phantom and in-vivo studies. The dynamic T1 time course can be traced successfully.

Impact: The porposed DART sequence is feasible to quantify the dynamic pixel-wised myocardial T1 values with sufficient spatial-temporal resolution and whole heart coverage. It is potential useful to trace the dynamic response of myocardium during early gadolinium enhancement.

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Keywords