Keywords: Biomarkers, biomarkers, MRI-CEST sequence
Motivation: Patients with long-term chronic kidney disease experience disorders in myocardial energy metabolism disorders, further leading to cardiac function impairment.
Goal(s): To evaluate myocardium creatine level using chemical exchange saturation transfer (CEST) technique and assess its correlation with left ventricular (LV) dysfunction in end-stage renal disease (ESRD) patients.
Approach: Twenty-nine ESRD patients and 33 controls were included. Conventional cardiac MRI and CEST sequences were analyzed to calculate the correlations between myocardium creatine and LV function.
Results: ESRD patients exhibited lower creatine CEST value, indicating myocardial energy metabolism failure. This finding was associated with reduced LV ejection fraction, highlighting its significance in LV dysfunction.
Impact: Cardiac MRI CEST is a valuable technique for quantitatively measuring myocardial creatine levels, facilitating earlier diagnosis of myocardial energy metabolism failure, and guiding treatment in ESRD patients.
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