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Abstract #4348

Quantitative evaluation myocardium creatine in ESRD using MR CEST imaging: A Preliminary Study

Shiqi Jin1, Kangwei Jin1, Ruoxue Jia1, Ke Xue2, and Ting Liu1
1The First Hospital of China Medical University, Liaoning, China, 2MR Collaboration, United Imaging Research Institute of Intelligent Imaging, Beijing, China, Beijing, China

Synopsis

Keywords: Biomarkers, biomarkers, MRI-CEST sequence

Motivation: Patients with long-term chronic kidney disease experience disorders in myocardial energy metabolism disorders, further leading to cardiac function impairment.

Goal(s): To evaluate myocardium creatine level using chemical exchange saturation transfer (CEST) technique and assess its correlation with left ventricular (LV) dysfunction in end-stage renal disease (ESRD) patients.

Approach: Twenty-nine ESRD patients and 33 controls were included. Conventional cardiac MRI and CEST sequences were analyzed to calculate the correlations between myocardium creatine and LV function.

Results: ESRD patients exhibited lower creatine CEST value, indicating myocardial energy metabolism failure. This finding was associated with reduced LV ejection fraction, highlighting its significance in LV dysfunction.

Impact: Cardiac MRI CEST is a valuable technique for quantitatively measuring myocardial creatine levels, facilitating earlier diagnosis of myocardial energy metabolism failure, and guiding treatment in ESRD patients.

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