Keywords: Dementia, Dementia
Motivation: Mild cognitive impairment (MCI) is prevalent in end-stage renal disease (ESRD), potentially due to glymphatic dysfunction impacting waste clearance.
Goal(s): This study aims to investigate glymphatic function in ESRD-MCI patients by assessing choroid plexus volume (CPV) and diffusion tensor imaging along the perivascular space (DTI-ALPS) index.
Approach: We compared cognitive performance, CPV and DTI-ALPS index between ESRD-MCI and healthy controls (HC). Employing mediation analysis to examine CPV’s role in linking glymphatic dysfunction to MCI.
Results: ESRD-MCI showed significantly lower DTI-ALPS index and higher CPV than HC. CPV mediated the relationships between ESRD status, reduced DTI-ALPS index, and executive dysfunction.
Impact: This study identifies choroid plexus volume as a potential mediator of glymphatic dysfunction and executive dysfunction in ESRD-MCI, suggesting its role in cognitive impairment pathophysiology. This finding offers a target for interventions to address cognitive decline in ESRD patients.
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