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Abstract #4352

Choroid plexus volume mediates glymphatic and executive dysfunction in end-stage renal disease patients with mild cognitive impairment

Zhaoyao Luo1, Lurui Bo1,2, Xiang Chen3, Yanran Chen1, Hengchang Zhang1,2, Zhengshu Han1,2, Jiayue Wang1,2, Ziyi Wang1,2, Xinyi Wang1, Xinyi Zhu1, Qiange Zhu1, Huijie Yuan1, Wen Gu1, Siyao Liu1, Shaohui Ma1, Junya Mu1, and Yuchen Liu4
1Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, 2Xi'an Jiaotong University, Xi'an, China, 3The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China, 4GE HealthCare MR Research, Beijing, China

Synopsis

Keywords: Dementia, Dementia

Motivation: Mild cognitive impairment (MCI) is prevalent in end-stage renal disease (ESRD), potentially due to glymphatic dysfunction impacting waste clearance.

Goal(s): This study aims to investigate glymphatic function in ESRD-MCI patients by assessing choroid plexus volume (CPV) and diffusion tensor imaging along the perivascular space (DTI-ALPS) index.

Approach: We compared cognitive performance, CPV and DTI-ALPS index between ESRD-MCI and healthy controls (HC). Employing mediation analysis to examine CPV’s role in linking glymphatic dysfunction to MCI.

Results: ESRD-MCI showed significantly lower DTI-ALPS index and higher CPV than HC. CPV mediated the relationships between ESRD status, reduced DTI-ALPS index, and executive dysfunction.

Impact: This study identifies choroid plexus volume as a potential mediator of glymphatic dysfunction and executive dysfunction in ESRD-MCI, suggesting its role in cognitive impairment pathophysiology. This finding offers a target for interventions to address cognitive decline in ESRD patients.

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