Abstract #4364

Mendelian randomization analysis reveals causal relationships between iron loading in subcortical regions and the risk of developing dementia

Yiwen Chen¹, Tao Chen², Linfeng Yang², Pengcheng Liang¹, Zhenyu Cheng³, Na Wang¹, Xinyue Zhang¹, Yuanyuan Wang³, Chaofan Sui¹, Yian Gao¹, Changhu Liang¹, and Lingfei Guo¹

¹Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ²Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China, ³School of Medical Imaging, Binzhou Medical University, Yantai, China

Synopsis

Keywords: Other Neurodegeneration, Dementia

Motivation: Observational studies showed a relationship between iron levels in subcortical regions and cognition. However, the causal association between them remains unclear.

Goal(s): To explore the causal associations between iron levels in subcortical regions and cognitive impairment.

Approach: Two-sample mendelian randomization (MR) analysis was performed based on genome-wide association study (GWAS) data.

Results: Meaningful IVW (primary method) results were identified, and their consistent direction was confirmed in all three methods. Most results were nominally significant. We did not detect horizontal pleiotropy. The leave-one-out test confirmed that these associations were reliable.

Impact: Iron deposition in subcortical brain regions raises the risk of dementia, and subcortical susceptibility values can be used as an imaging biomarker for the clinical assessment of dementia.

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