Keywords: Aging, Aging, Contrast Mechanism, Oxygenation, fMRI (task-based)
Motivation: Aging significantly impacts cerebrovascular and metabolic functions, potentially contributing to cognitive decline and neurodegeneration. Imaging biomarkers such as CBF, CVR, OEF, and CMRO₂ provide insight into these changes.
Goal(s): To investigate age-related alterations in cerebrovascular and metabolic metrics using dual-calibrated fMRI.
Approach: We employed dynamic PCASL with hyperoxic and hypercapnic gas challenges on young and elderly participants, using voxel-wise analysis to assess the effects of age on CBF, CBF-CVR, OEF, and CMRO₂.
Results: Age-related global reductions in CBF and regional declines in CBF-CVR and CMRO₂ underscore the importance of multi-metric imaging in understanding cerebrovascular and metabolic aging.
Impact: This study reveals age-related declines in global and regional cerebrovascular and metabolic metrics, providing critical insights into brain aging. These findings support the utility of multi-metric imaging for understanding mechanisms of cognitive decline and neurodegenerative disease progression.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords